Malarone Tablets (per tablet) Prescription only

Each Malarone tablet contains the two active ingredients Atovaquone 250mg and Proguanil 100mg which both work in combination to prevent malaria.

• Adult dose is one tablet daily - each tablet contains 250mg atovaquone plus 100mg proguanil. It is licensed for children over 11kg of weight at a lower dosage and a children's tablet is available.
• Should be taken to 1 or 2 days before entering the malarious area, throughout exposure, and continued for 7 days after leaving the infected area. Licensed for stays in malarious areas for periods of up to 28 days but can be used safely for up to 1 year (and possibly longer).
• Take your tablets with food at the same time each day. If you miss a dose or vomit within one hour of taking your tablets, take another dose and carry on as before (you may have to get more tablets). If you have diarrhoea, continue taking your tablets as normal. It is very important to complete the course.
• Side effects may include: rashes, abdominal pain, headache, anorexia, nausea, diarrhoea, dizziness, change in sleep pattern, coughing and mouth ulcers can occur.
• Absorption of this medicine may be reduced by diarrhoea and vomiting.
• Atovaquone/proguanil may interact with other medicines if taken at the same time. These include: tetracyclines, metoclopramide, rifampicin, rifabutin or indinavir.
• Proguanil can affect the anticoagulant, warfarin, which may result in bleeding. If it has to be used, re-stabilising the prothrombin time before departure is advised. It may be necessary to monitor blood levels whilst overseas and on return.
• Those with kidney disease should be assessed carefully before taking this medication. Should be avoided in pregnancy and breast feeding unless there is no suitable alternative.
• Pregnancy should be avoided for 2 weeks after stopping the medication

View patient leaflet

The choice of antimalarial changes periodically and can vary within different regions of the same country. Malarone is one of several medicines in the UK used to prevent malaria. Please check which anti-malaria product is currently needed for your particular destination(s) by visiting the fit for Travel site here.